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In clinical trials, there was no excess of myopathy or rhabdomyolysis associated with ezetimibe compared with the relevant control arm (placebo or statin alone).

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The Cochrane database of systematic reviews (10): CD006015.

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The use of the A1C for the diagnosis of diabetes is not recommended at this time.

The committee also struggled with drugmaker Merck's request to apply the results of the IMPROVE-IT trial in acute coronary syndrome patients to the more general population of coronary heart disease patients.

Body of evidence is weak and recommendation must be applied with caution.

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Plasma coenzyme Q10 predicts lipid-lowering response to high-dose atorvastatin.

Combined use of probucol and cilostazol with atorvastatin attenuates atherosclerosis in moderately hypercholesterolemic rabbits.

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Other studies have shown that adding ezetimibe to a statin further reduces blood cholesterol levels; however, the drug's effect on clinical outcomes, such as heart attacks, stroke, and cardiovascular death, are unknown.

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The coadministration of ZETIA with fibrates other than fenofibrate is not recommended until use in patients is adequately studied.

The systematic literature review was undertaken according to the process outlined in the National Health and Medical Research Council (NHMRC) Standards and Procedures for Externally Developed Guidelines (2007) by an external group from the International Centre for Allied Health Evidence (iCAHE), University of South Australia.

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One such agent is ezetimibe, a cholesterol absorption inhibitor that targets uptake at the jejunal enterocyte brush border.

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